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PRODUCT FOCUS - BENZENE-1,2-DIAMINES
Benzene-1,2-diamines are bifunctional, nucleophilic compounds which are used as starting materials and building blocks in a wide range of synthetic processes. Functionalised benzene-1,2-diamines are precursors to a number of bicyclic, nitrogen heterocycles, like benzimidazoles, benzotriazoles and 1,5-benzodiazepines, all of which feature prominently in the core structures of a number of pharmaceuticals with benzimidazole and benzotriazole derivatives possessing antibacterial and antiviral properties1 and 1,5-benzodiazepines being potent anxiolytic2 and sedative drugs. Using pre-functionalised benzene-1,2-diamine building blocks could unlock a wider range of novel heterocyclics which offer potential in pharmaceutical development.

One of the most common applications of functionalised benzene-1,2-diamines and their derivatives is their use as ligands in metal complexes. The two adjacent nitrogens on the aromatic ring are positioned such that they are both capable of binding to a central cation, hence their prominence in multidentate ligands such as Schiff bases, which are used as catalysts in a number of important reactions and as chemosensors3. The bidentate nature of benzene-1,2-diamines has been utilised by chemists in the design of macrocyclic compounds too, with DBTA crown ethers being used as chelating agents4.

Benzene-1,2-diamines can also be used as precursors to corrosion inhibitors5, antioxidants, fluorescent probes6 and in herbicides and pesticides.

A wide range of benzene-1,2-diamines are available from stock at Apollo with others available on request.

1 Bioorg. Med. Chem. Lett., 2015, 25, 3730-3737
2 Theraputic Advances in Neurological Disorders, 2014, 7, 169-176
3 Journal of Luminescence, 2015, 165, 167-173
4 J. Org. Chem., 2005, 70, 5804-5817
5 International Journal of ChemTech Research, 2051,7, 279-286
6 Journal of Fluorescence, 2016, 26, 53-57

OR22977
4-Bromobenzene-1,2-diamine
5g £25.00
25g £80.00
100g £174.00
4-Bromophenylene-1,2-diamine, 3,4-Diaminobromobenzene
OR4932
4,5-Dichlorobenzene-1,2-diamine 98%
5g £34.00
25g £88.00
100g £326.00
1,2-Diamino-4,5-dichlorobenzene, 4,5-Dichlorophenylene-1,2-diamine
OR61025
4-(Methylsulphonyl)benzene-1,2-diamine
1g £120.00
1,2-Diamino-4-(methylsulphonyl)benzene, 3,4-Diaminophenyl methyl sulphone, 4-(Methylsulphonyl)phenylene-1,2-diamine
OR70018
3-Bromo-5-methylbenzene-1,2-diamine
1g £210.00
3-Bromo-5-methylphenylene-1,2-diamine, 3-Bromo-4,5-diaminotoluene
PC0143
3,5-Difluorobenzene-1,2-diamine
1g £24.00
5g £96.00
25g £240.00
3,5-Difluorophenylene-1,2-diamine, 1,2-Diamino-3,5-difluorobenzene
PC0342
4,5-Difluorobenzene-1,2-diamine
1g £32.00
5g £84.00
25g £240.00
4,5-Difluorophenylene-1,2-diamine, 1,2-Diamino-4,5-difluorobenzene
PC2478
4-Bromo-5-(trifluoromethoxy)benzene-1,2-diamine 97%
1g £95.00
5g £295.00
4-Bromo-5-(trifluoromethoxy)phenylene-1,2-diamine
PC32696
N1-Methyl-4-(trifluoromethyl)benzene-1,2-diamine
250mg £26.00
1g £65.00
5g £252.00
3-Amino-4-(methylamino)benzotrifluoride, 2-Amino-1-(methylamino)-4-(trifluoromethyl)benzene
PC3920
3,4,5-Trifluorobenzene-1,2-diamine
1g £195.00
3,4,5-Trifluorophenylene-1,2-diamine
PC48404
3-Bromo-5-(trifluoromethoxy)benzene-1,2-diamine
250mg £15.00
1g £45.00
5g £180.00
3-Bromo-5-(trifluoromethoxy)phenylene-1,2-diamine, 1-Bromo-2,3-diamino-5-(trifluoromethoxy)benzene
PC5164
4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine 97%
1g £85.00
5g £245.00
4-Chloro-5-(trifluoromethyl)phenylene-1,2-diamine
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